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By A. Rendle Short and C. I. Ham (Auth.)

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Nearly 100 mm. of mercury—while oxygen tension in the tissues is almost zero. , to plasma, where tension is about 35 mm. (arterial). Dissociation of oxyhaemoglobin is probably helped by this increased tension of C0 2 . —Tissues have a great affinity for oxygen. In animal killed shortly after intravenous injection of méthylène blue, blood is found to be blue, but muscles are a normal colour. On exposure to air, tissues become blue, showing t h a t muscles had removed oxygen from the méthylène blue.

Basal metabolism is increased in Graves' (From C. L. ) and starvation. —Collect expired air in Douglas bag. Analyse for oxygen and CO a . Result is converted into calories by calculating-tables. — NITROGEN. — Apparently in simple solution. Evidence : (1) Amount present in blood corresponds with this view ; (2) Varies directly with pressure of nitrogen. c. c. of oxygen, 19-7 being combined with the haemoglobin of the red bloodcorpuscles. The remaining 0·3 per cent is dissolved in the plasma according to the ordinary laws of diffusion.

He also observed a rise in portal blood-pressure, dilatation of intestinal vessels, and extravasations in intestine. 3. Injection of crystalline substances such as NaCl or glucose leads to increased flow of dilute lymph without a rise in arterial blood-pressure, so apparently increased flow is not due to increased filtration (Heidenhain). —Starling has shown that intracapillary pressure may be increased, and considers rise of osmotic pressure following injection of these salts leads to hydraemic plethora, followed by increased outflow into lymphvessels.

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