By Urs von Stockar (Editor), Luuk van der Wielen (Editor)
Approach integration has been probably the most lively learn fields in Biochemical Engineering during the last decade and it'll remain so if bioprocessing is to turn into extra rational, effective and effective. This quantity outlines what has been accomplished in recent times. Written by means of specialists who've made very important contributions to the ecu technology, starting place application on strategy Integration in Biochemical Engineering, the amount makes a speciality of the growth made and the foremost possibilities, and also at the barriers and the demanding situations in bioprocess integration that lie forward. the idea that of bioprocess integration is taken care of at a number of degrees, together with integration on the molecular, organic, bioreactor and plant degrees, but in addition accounting for the combination of separation and mass move operations and biology, fluid dynamics and body structure, in addition to uncomplicated technological know-how and technique expertise.
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Additional resources for Advances in Biochemical Engineering & Biotechnology, Volume 080: Process Integration in Biochemical Engineering
At a first glance, this part of the dynamic response is neither surprising nor really interesting. What can be observed is a remarkable increase of flux, which results in acetate excretion (not shown) after a short time delay. There are, however, clear signs that the initial response points to a delay in the abrupt increase of the uptake. This behavior would have enormous implications in the dynamic behavior of the cells traveling through regions of varying concentrations within the bioreactor.
Notice that the second production term is related to the time scale tp . The introduction of this additional term enables the energy transfer to respond more efficiently to the mean strain than the standard k– e model does. Thus, tp enables the development of a field of e suppressing the wellknown overshoot phenomenon of the turbulent kinetic energy k. This overshoot appears, when the standard k– e model is applied to flow conditions with large values of mean strain [4, 7, 8]. The modification may be summarized as follows: e production appears in two energy fluxes divided by two different timescales td and tp .
Equation (15) becomes: ∂p 3 r 0= + cd L Du Dui (32) ∂ xi 4 db 38 S. Schmalzriedt et al. The simulation procedure is then simplified and includes the following steps: (1) Simulation of liquid phase with reduced pumping capacity of the impellers. (2) Estimation of the representative bubble diameter. (3) Solution of the simplified momentum balance equation of the gas phase (Eq. (32)). (4) Solution of a balance equation for the specific gas hold-up: ∂eG ∂eG Ê ∂eG ˆ + uiG Á Deff ˜ + SG Ë ∂t ∂ xi ∂ xi ¯ with SG = (33) V˙G Vi at the location of the gas sparger.