By Robert K. Poole
Advances in Microbial Physiology is without doubt one of the such a lot winning and prestigious sequence from educational Press, an imprint of Elsevier. It publishes topical and significant studies, examining body structure to incorporate all fabric that contributes to our figuring out of the way microorganisms and their part components paintings.
First released in 1967, it really is now in its sixty fourth quantity. The Editors have continually striven to interpret microbial body structure within the broadest context and feature by no means constrained the contents to “traditional perspectives of entire mobile body structure. Now edited via Professor Robert Poole, collage of Sheffield, Advances in Microbial Physiology is still an influential and extremely good reviewed sequence.
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Extra resources for Advances in Microbial Systems Biology
We considered that this limited response was not in agreement with the key role of potassium in the yeast physiology and, consequently, we developed a complementary approach based in the use of the Translucent K+-free medium and aiming to investigate the short-term effects on gene expression profile derived from the sudden depletion of potassium in the environment. We demonstrated that transfer of wild-type S. cerevisiae cells to K+-free medium results in a strong short-term transcriptional response that affects over one thousand genes.
1. Impact on flocculation and invasiveness The genome-wide transcriptional analysis described above and diverse research lines developed in parallel during Translucent 1 and 2 have uncovered or/and clarified unsuspected roles for potassium in yeast cells. One example is the recently reported link between potassium homeostasis and flocculation and invasiveness (Gonzalez, Casado, Petrezselyova, Ruiz, & Arino, 2013). , 2004). , 2009). We demonstrated that flocculence and invasiveness in the tetO:HAL3 vhs3 strain are caused by hyperactivation of Ppz1 as a result of depletion of its natural inhibitors.
We start with a brief introduction to the basic structure of the mathematical models and then summarize recent biological insights obtained from collaborative work of theoretical and wet lab biologists. 1. Principles of modelling ion regulation Mathematical models of ion regulation have to reflect both the biophysical and the molecular interactions (Weiss, 1996). We use the coupling between protons and potassium (Fig. , 2012). Extensions to more ions are then possible using the same model structure, but require more extensive experimental data and knowledge.