By Carol Bernstein, Harris Bernstein
Why organisms age and why sexual copy exists are significant unsolved difficulties in biology. This publication offers an built-in rationalization of getting older and intercourse in accordance with present wisdom of DNA harm and service. Key good points* Discusses the universality of the matter of DNA harm* Describes getting older due to amassed DNA harm* Considers meiosis as an edition for DNA fix* Discusses mating in eukaryotes as an variation for protecting mutation. Read more...
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Extra resources for Aging, Sex, and DNA Repair
1974), a n u m b e r of investigators h a v e s h o w n that the D N A synthesized shortly after the UVirradiation of E. coli, h u m a n , and other mammalian cell lines has a lower molecular weight than D N A synthesized in nonirradiated cells. T h e sizes of these low-molecular weight D N A segments in E. coli, m o u s e , and h u m a n cells a p p r o x i m a t e d the average distance b e t w e e n U V - i n d u c e d pyrimidine dimers in the parental D N A . T h e s e data support the notion that pyrimidine dimers interrupt normal D N A replication and that synthesis r e s u m e s b e y o n d the dimer.
This study suggests that excision repair capacity declines as this type of neuronal cell differentiates from the mitotic to the postmitotic state. Gensler (1981a, 1981b) found that unscheduled D N A synthesis in r e s p o n s e to U V irradiation (a m e a s u r e of pyrimidine dimer excision repair) is markedly lower in m a t u r e h a m s t e r brain than in mature h a m s t e r lung or kidney cells. T h e capacity of brain cells to carry out excision repair declined threefold early in life (between ages 1 and 7 wk).
Ames, B . N . (1989). Endogenous DNA damage as related to cancer and aging. Mutat. Res. 214, 41-46. Anderson, C. T. , and Friedberg, E. C. (1980). The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells. Nucleic Acid Res. 8, 875-888. Barrows, L. , and Magee, P. N. (1982). Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro. Carcinogenesis 3, 349-351. , Byerly, H. C , Hopf, F. , and Michod, R. E. (1985). The evolutionary role of recombinational repair and sex.