Download Aging, Sex, and DNA Repair by Carol Bernstein, Harris Bernstein PDF

By Carol Bernstein, Harris Bernstein

Why organisms age and why sexual copy exists are significant unsolved difficulties in biology. This publication offers an built-in rationalization of getting older and intercourse in accordance with present wisdom of DNA harm and service. Key good points* Discusses the universality of the matter of DNA harm* Describes getting older due to amassed DNA harm* Considers meiosis as an edition for DNA fix* Discusses mating in Read more...

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Extra resources for Aging, Sex, and DNA Repair

Sample text

1974), a n u m b e r of investigators h a v e s h o w n that the D N A synthesized shortly after the UVirradiation of E. coli, h u m a n , and other mammalian cell lines has a lower molecular weight than D N A synthesized in nonirradiated cells. T h e sizes of these low-molecular weight D N A segments in E. coli, m o u s e , and h u m a n cells a p p r o x i m a t e d the average distance b e t w e e n U V - i n d u c e d pyrimidine dimers in the parental D N A . T h e s e data support the notion that pyrimidine dimers interrupt normal D N A replication and that synthesis r e s u m e s b e y o n d the dimer.

This study suggests that excision repair capacity declines as this type of neuronal cell differentiates from the mitotic to the postmitotic state. Gensler (1981a, 1981b) found that unscheduled D N A synthesis in r e s p o n s e to U V irradiation (a m e a s u r e of pyrimidine dimer excision repair) is markedly lower in m a t u r e h a m s t e r brain than in mature h a m s t e r lung or kidney cells. T h e capacity of brain cells to carry out excision repair declined threefold early in life (between ages 1 and 7 wk).

Ames, B . N . (1989). Endogenous DNA damage as related to cancer and aging. Mutat. Res. 214, 41-46. Anderson, C. T. , and Friedberg, E. C. (1980). The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells. Nucleic Acid Res. 8, 875-888. Barrows, L. , and Magee, P. N. (1982). Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro. Carcinogenesis 3, 349-351. , Byerly, H. C , Hopf, F. , and Michod, R. E. (1985). The evolutionary role of recombinational repair and sex.

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