By Edited by: Daniel L. Purich, Daniel L. Purich
This publication is an element A in a subseries entitled "Amino Acid Metabolism". subject matters partially A might be of fast curiosity to people who are largely considering amino acid assimilation and metabolism. Investigators attracted to enzyme mechanism and law also will locate this quantity in particular important.
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Extra resources for Amino Acid Metabolism, Part A, Volume 72, Advances in Enzymology and Related Areas of Molecular Biology
Both D- and L-glutamate were effective in the enzyme-catalyzed synthesis of the D and L forms of pyrrolidone carboxylate, a finding that was consistent with the generally recognized ability of the enzyme to use either enantiomer of glutamate. Well aware that y-glutamyl derivatives are far more susceptible to nonenzymatic cyclization, Krishnaswamy et al. (1962) went on to demonstrate that glutamine formed the pyrrolidone-carboxylate some 600 times more slowly than in the corresponding enzymic step observed in the above experiment.
However, within the enzyme-bound state, the internal equilibrium Enz[ATPglutamate] = Enz[ADPglutamyl-PI may favor the acyl-P as a result of enzyme stabilizationof the bound intermediate. Arguing in favor of this interpretation are the data of Krishnaswamy et al. C). 2 p M of the cyclic product ADVANCES IN THE ENZYMOLOGY OF GLUTAMINE SYNTHESIS 27 from L- and D-glutamate, respectively, in the presence of 22-pM sheep brain glutamine synthetase, which as noted earlier utilizes either enantiomer. Their values correspond to 76 and 77% of the total available enzyme sites, and their values are remarkably similar to those reported for borohydride reduction experiments with the bacterial enzyme (Todhunter and Purich, 1975).
Transport Hepatic Glutamine Metabolism A. Regulation of Glutamine Breakdown I . Short-Term Regulation 2. Long-Term Regulation B. Regulation of Glutamine Synthesis Integration of Glutamine Metabolism at the Acinar Level: Functional Relevance A. Glutamine Synthase as Perivenous Ammonia Scavenger B. Glutaminase: A pH and Hormone-Controlled Ammonia Amplifying System C. Intercellular Glutamine Cycling D. Role in Acid-Base Homeostasis ~~ Advances in Enzymology and Related Areas of Molecular Biology, Volume 72: Amino Acid Metabolism, Part A , Edited by Daniel L.