Download Amyloid, Prions, and Other Protein Aggregates, Part C by Ronald Wetzel, Indu Kheterpal PDF

By Ronald Wetzel, Indu Kheterpal

The power of polypeptides to shape on the other hand folded, polymeric buildings reminiscent of amyloids and similar aggregates is being more and more famous as an important new frontier in protein examine. This new quantity of tools in Enzymology besides half B (volume 412) on Amyloid, Prions and different Protein Aggregates proceed within the culture of the 1st quantity (309) in containing unique protocols and methodological insights, supplied by way of leaders within the box, into the newest tools for investigating the buildings, mechanisms of formation, and organic actions of this crucial category of protein assemblies.

* provides particular protocols
* contains troubleshooting assistance
* presents assurance on structural biology, computational equipment, and biology

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Brems, D. , and Li, W. Y. (1994). Secondary structure of amyloid peptide correlates with neurotoxic activity in vitro. Mol. Pharmacol. 45, 373–379. , Castano, E. , Kumar, R. , Beavis, R. , and Frangione, B. (1995). Fibrillogenesis of synthetic amyloid‐ peptides is dependent on their initial secondary structure. Neurosci. Lett. 200, 105–108. Stine, W. , Dahlgren, K. , Krafft, G. , and LaDu, M. J. (2003). In vitro characterization of conditions for amyloid‐ peptide oligomerization and fibrillogenesis.

Przybyla, A. , and Zagorski, M. G. (2004). Solution NMR studies of the A (1‐40) and A (1‐42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. J. Am. Chem. Soc. 126, 1992–2005. Howlett, D. , Jennings, K. , Lee, D. , Clark, M. , Wood, S. , and Roberts, G. W. (1995). Aggregation state and neurotoxic properties of Alzheimer ‐amyloid peptide. Neurodegeneration 4, 23–32. Huang, T. , Yang, D. , Plaskos, N. , Yip, C. , Fraser, P. , and Chakrabartty, A. (2000).

2004). Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron 44, 181–193. Wang, H. , Pasternak, J. , Lambert, M. , Viola, K. , Klein, W. , Stine, W. , Krafft, G. , and Trommer, B. L. (2002). Soluble oligomers of amyloid (1‐42) inhibit long‐term potentiation but not long‐term depression in rat dentate gyrus. Brain Res. 924, 133–140. Wood, S. , and Wetzel, R. (1996). 4 aggregates of the Alzheimer’s amyloid peptide A . J. Mol. Biol. 256, 870–877. Zagorski, M. , and Barrow, C.

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