By Tetsuzo Akutsu, Hitoshi Koyanagi, Setsuo Takatani, Kazunori Kataoka, Jack G. Copeland, Stuart L. Cooper, Peer M. Portner, David B. Geselowitz
Read Online or Download Artificial Heart 2: Proceedings of the 2nd International Symposium on Artificial Heart and Assist Device, August 13–14, 1987, Tokyo, Japan PDF
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Extra resources for Artificial Heart 2: Proceedings of the 2nd International Symposium on Artificial Heart and Assist Device, August 13–14, 1987, Tokyo, Japan
The prolongation of the thrombin time of the covalently heparinized polyurethane suggests present polyurethanes is summarized in Fig. 11. that the immobilized heparin can deactivate throm- Short-term blood compatibility can be obtained by bin. Moreover, ionically heparinized polyurethane heparinization. Approaches to long-term blood comsuppressed the platelet adhesion and activation of patibility remain a subject for future research. adhered platelets. Heparinized polyurethanes with intervening spacer arms also exhibit antithrombo- Acknowledgments.
D (/) 50 0 D L_~~~~--~~~~~~~~~~~~~~ 102 10 3 10 . 10 5 10 6 Lifetime / sec hard segments have strong aggregation strength, did not show any reduction in fatigue strength. Even though PCL(2000)EDA has an MDI-EDA hard segment, this specimen showed reduction in fatigue strength; this is due to the phase mixing between the hard and soft segments caused by the interaction between ester group in the soft segment and urea group in the hard segment. The original SPUU containing the MDI-TriMDA hard segment showed a shorter fatigue lifetime than the SPUU containing the MDIEDA hard segment.
The nylon 610 column showed a rapid decrease in platelet elution in the first 10 min and was occluded within 30 min due to thrombosis. In contrast, the 61P3-25 and -47 columns showed almost constant platelet elution over 30 min . This figure indicates that adsorbed platelets on these copolymer surfaces were not so activated to accelerate thrombosis as those on the nylon 610 surface . 2 summarizes the results of these in vitro simulation tests for each polymer column . 2, the thrombosis time divided into 10-min intervals was obtained from eight separate experiments.