Download Artificial Intelligence and Molecular Biology (American by Lawrence E. Hunter PDF

By Lawrence E. Hunter

The huge, immense volume of knowledge generated by means of the Human Genome venture and different large-scale organic examine has created a wealthy and difficult area for examine in synthetic intelligence. those unique contributions offer a present sampling of AI ways to difficulties of organic value; they're the 1st to regard the computational wishes of the biology group hand-in-hand with acceptable advances in man made intelligence. targeting novel applied sciences and ways, instead of on confirmed purposes, they conceal genetic series research, protein constitution illustration and prediction, automatic facts research aids, and simulation of organic platforms. a quick introductory primer on molecular biology and Al supplies desktop scientists adequate heritage to appreciate a lot of the biology mentioned within the book.Lawrence Hunter is Director of the computer studying venture on the nationwide Library of medication, nationwide Institutes of Health.

Though this can be a outdated booklet (from 1993) nonetheless has strong primers &touches introductory topics.

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Sexual reproduction adds another dimension to the exchange of genetic material. DNA from the two parents of a sexually reproducing organism undergoes a process called crossover, which forms a kind of mosaic that is passed on to the offspring. Most mutations have relatively little effect. Mutations in the middle of introns generally have no effect at all (although mutations at the ends of an intron can affect the splicing process). Mutations in the third position of most codons have little effect at the protein level because of the redundancy of the genetic code.

The mixtures are then separated vertically by their charge and size. The gel is then stained, producing dark bands where a molecule of a given size or charge is present in a mixture. In this gel, the columns marked with a - are a control group. The band marked with an arrow is filled only in the + columns. distinctions, for example, mapping each protein in a cell to a unique spot in two-space, the size of the spot indicating the amount of the protein. Although there are still some difficulties in calibration and repeatability, this method is potentially a very powerful tool for monitoring the activities of large biochemical systems.

1990). DNA Data Bank of Japan: Present Status and Future Plans. Computers and DNA, 7, 47-61. , Benton, D. & Burks, C. (1990). The GenBank Nucleic Acid Data Bank. Focus, 11(4), 69-72. Ptashne, M. (1987). A Genetic Switch: Gene Control and the Phage Lambda. Palo Alto, CA: Blackwell Scientific Publications. Sauer, R. T. (1989). Genetic Analysis of Protein Stability and Function. Annual Review of Genetics, 23, 289-310. , Markley, J. & Kyogoku, Y. (1989). Creation of Nuclear Magnetic Resonance Data Repository and Literature Base.

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