Download Biochemistry of Collagens, Laminins and Elastin. Structure, by Morten Karsdal PDF

By Morten Karsdal

Biochemistry of Collagens, Laminins, and Elastin: constitution, functionality, and Biomarkers offers a finished advent to collagen and structural proteins. style I collagen is likely one of the so much considerable molecules within the physique, taking part in crucial roles in several tissues, fairly bone and pores and skin. A key element of style I collagen is its post-translational transformations that are crucial for proper synthesis and structural integrity of collagens, for tissue-specific performance, in addition to for program as biomarkers of other pathologies.

This quantity summarizes present info on key structural proteins (collagens, laminins and elastin), stories how those molecules impact pathologies, and describes chosen ameliorations of proteins that bring about altered signaling homes of the unique extracellular matrix part. additional, it discusses the radical idea that more and more elements of the ECM harbor cryptic signaling features that could be considered as endocrine services. also, it highlights how this data may be exploited to modulate fibrotic disease.

  • Provides a accomplished advent to collagen and structural proteins
  • Provides perception into rising analytical applied sciences that could discover biomarkers of extracellular matrix degradation
  • Includes a bankruptcy devoted to the biomarkers of structural proteins
  • Contains insights into the biochemical interactions and adjustments to structural composition of proteins in illness states

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Biochemistry of Collagens, Laminins and Elastin. Structure, Function and Biomarkers

Biochemistry of Collagens, Laminins, and Elastin: constitution, functionality, and Biomarkers presents a accomplished creation to collagen and structural proteins. kind I collagen is likely one of the such a lot ample molecules within the physique, taking part in crucial roles in several tissues, quite bone and epidermis.

Extra resources for Biochemistry of Collagens, Laminins and Elastin. Structure, Function and Biomarkers

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Transplantation 2003;75:2113–9. 28 Biochemistry of Collagens, Laminins and Elastin [24] Parkes J, Guha IN, Roderick P, Harris S, Cross R, Manos MM, et al. Enhanced Liver Fibrosis (ELF) test accurately identifies liver fibrosis in patients with chronic hepatitis C. J Viral Hepat 2011;18:23–31. [25] Oberti F, Valsesia E, Pilette C, Rousselet MC, Bedossa P, Aube C, et al. Noninvasive diagnosis of hepatic fibrosis or cirrhosis. Gastroenterology 1997;113:1609–16. [26] Guechot J, Laudat A, Loria A, Serfaty L, Poupon R, Giboudeau J.

Together, these studies show that regardless of whether the disease is associated with inflammation or fibrosis, the serum concentrations of protein fragments generated by specific proteases are increased in patients compared with healthy individuals. Furthermore, elevated levels of either one of the markers or both were associated with disease progression. This suggests that the pathological ECM remodeling can be monitored in different stages, from early disease onset with inflammation to the more advanced disease stages where fibrosis is present and that ECM remodeling is a common denominator in many diseases.

Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins. Int J Pept Protein Res 1987;30:808–21. [22] Cloos PA, Fledelius C. Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential. Biochem J 2000;345 Pt 3:473–80. [23] Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, et al. Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.

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