Download Claudins by Alan S. L. Yu (Eds.) PDF

By Alan S. L. Yu (Eds.)

This quantity of present issues in Membranes makes a speciality of Membrane Protein Crystallization, starting with a evaluation of previous successes and basic developments, then additional discussing demanding situations of mebranes protein crystallization, telephone unfastened creation of membrane proteins and novel lipids for membrane protein crystallization. This ebook additionally contains instruments to enchance membrane protein crystallization, approach developments, and crystallization options used for photosystem I and its complexes, setting up Membrane Protein Crystallization as a wanted, useful reference for researchers.

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2001). Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. Journal of Cell Biology, 153, 263–272. , et al. (2002). Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice. Journal of Cell Biology, 156, 1099–1111. , & Tsukita, S. (1993). Occludin: A novel integral membrane protein localizing at tight junctions. Journal of Cell Biology, 123, 1777–1788. , & Tsukita, S.

Introduction: Claudins, Tight Junctions, and the Paracellular Barrier 9 TABLE I Predicted Functions of Claudin Subtypes to Ion Permeation Evaluated in Overexpression or Knockdown in Cultured Epithelial Cells Claudin Predicted function Reference Clandin-1 Ion barrier Inai, Kobayashi, and Shibata (1999), McCarthy et al. (1996) Claudin-2 Cation channel Amasheh et al. (2002), Hou, Gomes, Paul, and Goodenough (2006), Van Itallie et al. (2003), Yu et al. (2009) Claudin-4 Cation barrier Van Itallie, Rahner, and Anderson (2001) Cation barrier or anion channel Hou et al.

Smith, T. , et al. (2001). Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29. Cell, 104, 165–172. , & Gumbiner, B. M. (1997). A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. Journal of Cell Biology, 136, 399–409. Yu, A. , Cheng, M. , Kanzawa, S. , Schneeberger, E. , et al. (2009). Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site.

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