Download Endocrinology and Physiology of Reproduction by Donald W. Pfaff, Rochelle S. Cohen (auth.), P. C. K. Leung, PDF

By Donald W. Pfaff, Rochelle S. Cohen (auth.), P. C. K. Leung, D. T. Armstrong, K. B. Ruf, W. H. Moger, H. G. Friesen (eds.)

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Extra resources for Endocrinology and Physiology of Reproduction

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From Merchenthaler et al. (1984), by courtesy of Cell and Tissue Research. (b) Electron micrographs of rat medial preoptic area immunostained for LHRH synaptic connections between labeled axons (arrows) and labeled cell bodies (LC). The synaptic membrane specializations (indicated by the small arrowheads) appear to be of the symmetric Gray II type. All of the labeled axons (arrows) contain pleimorphic-clear vesicles and a few dense-core vesicles. Bar scale = 1 ~m. From Leranth et al. (1985), by courtesy of Brain Research.

Astrada, J. , and Ta1eisnik, 1971b, Biphasic effect of progesterone on the release of gonadotrophin in rats, Endocrinology, 89:331. 33 Clarke, I. , Burman, K. , Doughton, B. , and Cummins, J. , 1986a, Effects of constant infusion of gonadotrophin-releasing hormone (GnRH) in ovariectomized ewes with hypothalamo-pituitary disconnection: further evidence for differential control of LH and FSH secretion and the lack of a priming effect, J. , in press. Clarke, I. , and Cummins, J. , 1982, The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes, Endocrinology, 111:1737.

Positive Feedback During the estrogen-induced LH surge in OVX ewes, we have observed ah increase in GnRH pulse frequency from approximately one pulse per h to two pulses per h (Clarke and Cummins, 1985a). A spectacular example of increased pulse frequency during the onset of the LH surge is seen in Fig. 2. This indicates the hypothalamic component of the positive feedback response. Using 'push-pull' perfusion of the median eminence and sampling OVX-estrogen treated ewes, Schillo et al. (1985) have found variable patterns of GnRH secretion associated with the LH surge.

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