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By Julio Collado-Vides, Ralf Hofestädt

Are the eyes homologous? -- Automation of protein series characterization and its software in entire proteome research -- details fusion and metabolic community regulate -- Specificity of protein-DNA interactions -- Genomics of gene legislation: the view from Escherichia coli -- Discovery of DNA regulatory motifs -- Gene networks description and modeling within the GeneNet process -- legislation of mobile states in mammalian cells from a genomewide view -- Predicting protein functionality and networks on a genomewide scale -- Metabolic pathways -- towards laptop simulation of the complete telephone

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Extra info for Gene regulation and metabolism : postgenomic computational approaches

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A list of new and changed proteins is created, and the calculation of similarities for this new set against itself and against unchanged proteins is carried out. uk/clustr. A query can be made using SPTR accession numbers, SWISS-PROT ID entry names, sequence annotation, key words, and taxonomic information. The result of the query is a graphical presentation of corresponding clusters at different levels of protein similarity. 1. 1 Searching the CluSTr database. Results for a query of ‘‘human sodium transport’’ proteins.

2000). PRINTS-S: The database formerly known as PRINTS. Nucleic Acids Res. 28: 225–227. , and Apweiler, R. (2000). The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res. 28: 45–48. Ball, C. , Dwight, S. , Harris, M. , Scafe, C. , et al. (2000). Integrating functional genomic information into the Saccharomyces Genome Database. Nucleic Acids Res. 28: 77–80. , Eddy, S. , Howe, K. , and Sonnhammer, E. L. L. (2000). The Pfam Protein Families Database. Nucleic Acids Res.

Tomb, J. , Dougherty, B. , Merrick, J. , et al. (1995). Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269: 496–512. , and Apweiler, R. (1999). A novel method for automatic and reliable functional annotation. Bioinfomatics 15: 228–233. The FlyBase Consortium. (1999). The FlyBase Database of the Drosophila Genome Projects and community literature. Nucleic Acids Res. 27: 85–88. , and Mewes, H. W. (1997). PEDANTic genome analysis. Trends in Genetics 13(10): 415–416.

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