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By Ricardo Macarrón, Robert P. Hertzberg (auth.), William P. Janzen, Paul Bernasconi (eds.)

In the years because the unencumber of the preferred first version, the sphere of excessive Throughput Screening (HTS) has developed significantly, from a small area of interest quarter of analysis to a big, crucial clinical process. In High Throughput Screening: equipment and Protocols, moment Edition, specialists within the box totally replace the former version to top function an advent to HTS for scientists who're simply coming into the sector, and as a supplier of key, major aspect in an effort to be beneficial to scientists in demonstrated HTS operations. that includes new screening applied sciences in addition to many good verified equipment, chapters supply accomplished remedy of the actions at once relating to HTS, comparable to compound library administration, info dealing with, and robotics. As a quantity within the hugely profitable Methods in Molecular Biology™ sequence, this paintings offers the type of meticulous description and implementation suggestion that's an important for purchasing optimum results.

Authoritative and intrinsically functional, High Throughput Screening: tools and Protocols, moment Edition can provide to proportion the top wisdom and exuberance with all those that use this flexible know-how of their personal labs.

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Extra resources for High Throughput Screening: Methods and Protocols, Second Edition

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2001) A homogeneous fluorescence polarization assay adaptable for a range of protein serine/threonine and tyrosine kinases. J Biomol Screen; 8:164–175. 12. Wu S, Liu B. (2005) Application of scintillation proximity assay in drug discovery. Biodrugs; 19:383–392. 13. Glickman J, Wu X, Mercuri R et al. (2002) A comparison of ALPHAScreen, TR-FRET, 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. and TRF as assay methods for FXR nuclear receptors. J Biomol Screen; 7:3–10. Debad JD, Glezer EN, Wohlstadter JN, Sigal GB.

Obviously proper management of indexes and table partitions is important for acceptable performance.

This can mean simple carriages that move the plate or more complex tracks that move the anthropomorphic arm. One of the earliest robotic systems used in biological laboratories was the ORCA from Beckman Coulter (Sagian). This is a four-axis arm with a plate gripper, mounted on a linear track of 1–3 meters. They Creation of a Small HTS Facility 37 have designed CORE systems around this transport system, with instruments lined up on both sides of the robot track. Similar systems have been developed by multiple companies, many with more robust robots (for example, Thermo CRS).

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