By R C Valentine; David L Valentine
''Human cells are shielded from the ravages of getting older through shielding structures together with novel mechanisms opposed to membrane oxidation brought during this ebook. The booklet proposes a unified thought during which getting older cells confronted with declining power creation through mitochondria and the really excessive price of defending membranes opposed to oxidation are brought on by way of power pressure to turn on programmed mobile dying. It includes case histories illustrating the duality of polyunsaturated membranes in getting older and sturdiness. It additionally explains the connection among membrane unsaturation and toughness resulting in a unified suggestion of getting older. ''--
''This booklet is equipped at the proposition that we age as our mitochondria age. we propose a revised model of Harman's recognized speculation that includes mitochondrial oxidative and effort stresses because the root factors of getting older. it's renowned that mobile dying or apoptosis is caused by means of strength tension or oxidative pressure. there's convincing information exhibiting that as mitochondria age mitochondrial DNA (mtDNA) accumulates mutations reducing strength output. conserving hugely unsaturated mitochondrial membranes opposed to oxidative rigidity additionally consumes a unprecedented volume of energy''-- Read more...
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Additional info for Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution
1b). This sparks an oxidative chain reaction that quickly spreads, robs the cells of energy, and shortly kills all of the cells forming the leaf surface. The leaf surface bleached by paraquat is devoid of active chloroplasts, and the photosynthetic energy production necessary for plant growth ceases. We suggest that plant death is caused in part by massive oxidatively mediated destruction of polyunsaturated chloroplast membranes resulting in uncoupling of the chloroplast’s bioenergetics. The roles of high-energy electrons in human diseases are discussed later, but further insight can be gained from looking more closely at paraquat’s mode of action in plants.
For example, isolates of some DHA bacteria from the deep sea grow within a temperature range from 0 to 10°C and are killed by temperatures above 10°C, while others grow to a temperature of 20°C, with death occurring at a few degrees above the maximum. DHA-producing isolates require seawater levels of salinity for growth, along with cold temperatures. 2 EPA-enriched membranes of a recombinant of E. coli serve as a surrogate for polyunsaturated membranes of mitochondria. This membrane fatty acid profile of an EPA recombinant of E.
Because these fatty acid mutants were not characterized at the genomic level, it is not possible to distinguish whether a regulatory versus a structural mutation is involved. We suggest that mutational analysis of polyunsaturated fatty acid-requiring mutants of bacteria would pay big dividends as surrogates of polyunsaturated mitochondrial membranes important in aging. 8 SUMMARY Data from Bacteria and Archaea demonstrate how membrane lipids contribute to cellular bioenergetics. Membranes play fundamental roles in both production and safeguarding or conservation of cellular energy supplies.