Download Learning and memory / 4. Molecular mechanisms of memory by J. David Sweatt PDF

By J. David Sweatt

This absolutely revised second edition provides the single unified synthesis of accessible info about the mechanisms of higher-order reminiscence formation. It spans the diversity from studying conception, to human and animal behavioral studying versions, to mobile body structure and biochemistry. it really is distinct in its incorporation of chapters on reminiscence issues, tying in those clinically vital syndromes with the elemental technology of synaptic plasticity and reminiscence mechanisms. It additionally covers state of the art ways corresponding to using genetically engineered animals in reports of reminiscence and reminiscence illnesses. Written in an attractive and simply readable variety and commonly illustrated with many new, full-color figures to assist clarify key strategies, this booklet demystifies the complexities of reminiscence and deepens the reader’s figuring out.

  • More than 25% new content material, quite increasing the scope to incorporate new findings in translational study.
  • Unique in its intensity of insurance of molecular and mobile mechanisms
  • Extensive cross-referencing to finished studying and reminiscence
  • Discusses clinically appropriate reminiscence problems within the context of contemporary molecular study and comprises various functional examples

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2001) Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. Science 294: 1547–1550. Antonova I, Lu F-M, Zablow L, and Hawkins RD (2005) Longlasting potentiation in hippocampal neurons is accompanied by a rapid increase in clusters of presynaptic proteins that persists at least three hours. Soc. Neurosci. Abstr. 13. Arancio O, Antonova I, Gambaryan S, et al. (2001) Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation. J. Neurosci.

20: RC82. Hayashi Y and Majewska AK (2005) Dendritic spine geometry: Functional implication and regulation. Neuron 46: 529–532. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, and Malinow R (2000) Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287: 2262–2267. Hegde AN, Inokuchi K, Pei WC, et al. (1997) Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89: 115–126.

1 Aplysia Withdrawal Reflexes and Underlying Neural Circuits One animal that is well suited for the examination of the molecular, cellular, morphological, and network mechanisms underlying neuronal plasticity and learning and memory is the marine mollusc Aplysia. This animal has a relatively simple nervous system with large, identifiable neurons that are accessible for detailed anatomical, biophysical, and biochemical studies. Neurons and neural circuits that mediate many behaviors in Aplysia have been identified.

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