Download Molecular Biology of Drug Addiction by Rafael Maldonado PDF

By Rafael Maldonado

A entire multidisciplinary evaluate of the main suitable molecular, genetic, and behavioral techniques used to enquire the neurobiological foundation of drug dependancy. The authors discover the newest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine dependancy, supply clean insights into the genetic foundation of drug habit and the hot healing views those have opened. They describe the expertise to be had to generate conditional knockout mice and convey how those mice can demonstrate the molecular foundation of opioid, psychostimulant, and cannabinoid dependancy. in addition they overview different behavioral versions on hand to guage the profitable results of gear and research the genes excited by alcohol dependence.

Show description

Read or Download Molecular Biology of Drug Addiction PDF

Similar molecular biology books

Xenopus laevis: Practical Uses in Cell and Molecular Biology

This quantity provides the 1st finished remedy of the wide variety of makes use of for Xenopus laevis oocytes and embryos in telephone and molecular biology. each one bankruptcy comprises heritage details, experimental protocols, and prompt functions. an in depth array of innovations is featured. The authors are skilled researchers who've written chapters that would be helpful to either skilled researchers and to these new to Xenopus as an experimental procedure.

Genomic Perl : from bioinformatics basics to working code

The critical Dogma -- DNA and RNA -- Chromosomes -- Proteins -- The important Dogma -- Transcription and Translation in Perl -- RNA Secondary constitution -- Messenger and Catalytic RNA -- degrees of RNA constitution -- Constraints on Secondary constitution -- RNA Secondary buildings in Perl -- Counting Hydrogen Bonds -- Folding RNA -- evaluating DNA Sequences -- DNA Sequencing and series meeting -- Alignments and Similarity -- Alignment and Similarity in Perl -- Predicting Species: Statistical types -- Perl Subroutine Libraries -- Species Prediction in Perl -- Substitution Matrices for Amino Acids -- extra on Homology -- Deriving Substitution Matrices from Alignments -- Substitution Matrices in Perl -- The PAM Matrices -- PAM Matrices in Perl -- series Databases -- FASTA structure -- GenBank layout -- GenBank's function destinations -- studying series records in Perl -- Object-Oriented Programming in Perl -- The SimpleReader type -- Hiding dossier codecs with process Inheritance -- neighborhood Alignment and the BLAST Heuristic -- The Smith-Waterman set of rules -- The BLAST Heuristic -- Preprocessing the question String -- Scanning the objective String -- enforcing BLAST in Perl -- records of BLAST Database Searches -- BLAST ratings for Random DNA -- BLAST ratings for Random Residues -- BLAST information in Perl -- examining BLAST Output -- a number of series Alignment I -- Extending the Needleman-Wunsch set of rules -- NP-Completeness -- Alignment Merging: A construction Block for Heuristics -- Merging Alignments in Perl -- discovering a very good Merge Order

Sorting and recycling endosomes

Sorting and Recycling Endosomes offers the most recent info on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos distinctive to lysosomes, Golgi, or plasma membrane. lately, the significance of endosomes as a sorting and recycling compartment has turn into more and more preferred.

Biochemistry of Collagens, Laminins and Elastin. Structure, Function and Biomarkers

Biochemistry of Collagens, Laminins, and Elastin: constitution, functionality, and Biomarkers presents a accomplished advent to collagen and structural proteins. sort I collagen is among the such a lot plentiful molecules within the physique, taking part in crucial roles in several tissues, fairly bone and pores and skin.

Extra info for Molecular Biology of Drug Addiction

Sample text

Lane, S. , Russell, D. , Vaidya, V. , Miserendino, M. , Rubin, C. , Duman, R. , and Nestler, E. J. (1996) Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. J. Pharmacol. Exp. Ther. 276, 306–315. , Cole, T. ,. Blendy, J. , and Schutz, G. (1994) Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc. Natl. Acad. Sci. USA 91, 5647–5651. Blendy, J. , Kaestner, K. , and Schutz, G. (1996) Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.

38. Mantamadiotis et al. tures in the expression of the physical morphine withdrawal syndrome. J. Pharmacol. Exp. Ther. 261, 669–677. Carlezon, W. , Olson, V. , Lane-Ladd, S. , Brodkin, E. , Duman, R. , Neve, R. , and Nestler, E. J. (1998) Regulation of cocaine reward by CREB. Science 282, 2272–2275. Widnell, K. , Self, D. , Lane, S. , Russell, D. , Vaidya, V. , Miserendino, M. , Rubin, C. , Duman, R. , and Nestler, E. J. (1996) Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens.

14, 47–93. 2. Shug, S. , and Grond, S. (1992) Adverse effects of systemic opioid analgesics. Drug Safety 7, 200–213. 3. Goldstein, M. D. (1994) From biology to drug policy. Freeman, New York. 4. van Ree, J. , Gerrits, M. , and Vanderschuren, L. J. (1999) Opioids, reward and addiction: an encounter of biology, psychology, and medicine. Pharmacol. Rev. 51, 341–396. 5. LaForge, K. , and Kreek, M. J. (2000) Opioid receptor and peptide gene polymorphisms: potential implications for addictions. Eur. J.

Download PDF sample

Rated 4.95 of 5 – based on 19 votes