By Michal Janitz
Written by way of major specialists from and academia, this primary unmarried complete source addresses contemporary advancements in subsequent iteration DNA sequencing expertise and their effect on genome learn, drug discovery and future health care. As such, it offers an in depth comparative research of commercially on hand structures in addition to insights into replacement, rising sequencing ideas. moreover, the publication not just covers the rules of DNA sequencing thoughts but in addition social, moral and advertisement facets, the concept that of custom-made drugs and a five-year point of view of DNA sequencing.Content:
Chapter 1 Sanger DNA Sequencing (pages 1–11): Artem E. males, Peter Wilson, Kirby Siemering and Susan Forrest
Chapter 2 Illumina Genome Analyzer II method (pages 13–28): Abizar Lakdawalla and Harper Vansteenhouse
Chapter three utilized Biosystems strong™ approach: Ligation?Based Sequencing (pages 29–42): Vicki Pandey, Robert C. Nutter and Ellen Prediger
Chapter four The Next?Generation Genome Sequencing: 454/Roche GS FLX (pages 43–56): Lei Du and Michael Egholm
Chapter five Polony Sequencing: historical past, know-how, and purposes (pages 57–76): Jeremy S. Edwards
Chapter 6 Next?Generation series facts research (pages 77–88): Leonard N. Bloksberg
Chapter 7 DNASTAR's Next?Generation software program (pages 89–94): Tim Durfee and Thomas E. Schwei
Chapter eight Real?Time DNA Sequencing (pages 95–101): Susan H. Hardin
Chapter nine Direct Sequencing by means of TEM of Z?Substituted DNA Molecules (pages 103–116): William ok. Thomas and William Glover
Chapter 10 A unmarried DNA Molecule Barcoding strategy with functions in DNA Mapping and Molecular Haplotyping (pages 117–132): Ming Xiao and Pui?Yan Kwok
Chapter eleven Optical Sequencing: Acquisition from Mapped Single?Molecule Templates (pages 133–151): Shiguo Zhou, Louise Pape and David C. Schwartz
Chapter 12 Microchip?Based Sanger Sequencing of DNA (pages 153–163): Ryan E. Forster, Christopher P. Fredlake and Annelise E. Barron
Chapter thirteen Multiplex Sequencing of Paired finish Ditags for Transcriptome and Genome research (pages 165–182): Chia?Lin Wei and Yijun Ruan
Chapter 14 Paleogenomics utilizing the 454 Sequencing Platform (pages 183–199): M. Thomas P. Gilbert
Chapter 15 ChIP?Seq: Mapping of Protein–DNA Interactions (pages 201–215): Anthony Peter Fejes and Steven J. M. Jones
Chapter sixteen MicroRNA Discovery and Expression Profiling utilizing Next?Generation Sequencing (pages 217–228): Eugene Berezikov and Edwin Cuppen
Chapter 17 DeepSAGE: Tag?Based Transcriptome research past Microarrays (pages 229–244): Kare L. Nielsen, Annabeth H. Petersen and Jeppe Emmersen
Chapter 18 the recent Genomics and private Genome info: moral concerns (pages 245–254): Jeantine E. Lunshof
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Additional info for Next Generation Genome Sequencing: Towards Personalized Medicine
KGaA, Weinheim ISBN: 978-3-527-32090-5 j15 2 Illumina Genome Analyzer II System Abizar Lakdawalla and Harper VanSteenhouse With the ability to sequence more than 60 000 000 DNA fragments simultaneously, the ﬁrst generation of the Illumina Genome Analyzer had revolutionized the ability of labs to generate large volumes of sequence data in just a week at an extremely low cost; data that previously required the resources of a genome center, the efforts of many scientists over many months, and an expenditure of millions of dollars [1, 2].
And Brown, C. (2005) Toward the $1000 human genome. Pharmacogenomics, 6, 373–382. 11 Bailo, E. and Deckert, V. (2008) Tipenhanced Raman spectroscopy of single RNA strands: towards a novel directsequencing method. Angewandte Chemie, 4, 1658–1661. j11 Part Two Next-Generation Sequencing: Toward Personalized Medicine Next-Generation Genome Sequencing: Towards Personalized Medicine. Edited by Michal Janitz Copyright Ó 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ISBN: 978-3-527-32090-5 j15 2 Illumina Genome Analyzer II System Abizar Lakdawalla and Harper VanSteenhouse With the ability to sequence more than 60 000 000 DNA fragments simultaneously, the ﬁrst generation of the Illumina Genome Analyzer had revolutionized the ability of labs to generate large volumes of sequence data in just a week at an extremely low cost; data that previously required the resources of a genome center, the efforts of many scientists over many months, and an expenditure of millions of dollars [1, 2].
2007) Enrichment of supersized resequencing targets from the human genome. Nature Methods, 4, 891–892. 7 Wold, B. M. (2008) Sequence census methods for functional genomics. Nature Methods, 5 (1), 19–21. L. and Varshney, A. (2007) High-throughput sequence alignment using Graphics Processing Units. BMC Bioinformatics, 8 (1), 474. , Borodina, T. and Himmelbauer, H. (2007) SHARCGS, a fast and highly accurate short-read assembly algorithm for de novo genomic sequencing. Genome Research, 17, 1697–1706.