By Ondrej Slaby, George A. Calin
This is the 1st ebook to supply a wide framework for acquiring a close knowing of the state of the art wisdom on abnormalities of non-coding RNAs came upon to be linked to colorectal melanoma pathogenesis. Readers will become aware of attainable mechanisms underlying the mammoth roles performed by means of non-coding RNAs in molecular hallmarks of colorectal melanoma.
This paintings extra offers the great review and novel insights into utilizing of non-coding RNAs as colorectal melanoma biomarkers allowing early detection of the sickness, prognostic stratification of the sufferers and prediction of healing reaction.
The reader is brought to the assessment of recent non-coding RNAs-based healing innovations, and precis in their preclinical trying out played in colorectal melanoma. The paintings is written for researchers who are looking to discover present kingdom of the information during this fascinating box of molecular oncology.
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Extra info for Non-coding RNAs in Colorectal Cancer
2016;36(4):716–26. 6. Venkatesh T, Suresh PS, Tsutsumi R. Non-coding RNAs: functions and applications in endocrinerelated cancer. Mol Cell Endocrinol. 2015;416:88–96. 7. Cowie P, Hay EA, MacKenzie A. The noncoding human genome and the future of personalised medicine. Expert Rev Mol Med. 2015;17:e4. 8. Quinn JJ, Chang HY. Unique features of long noncoding RNA biogenesis and function. Nat Rev Genet. 2015;17(1):47–62. 9. Muhammad S, Kaur K, Huang R, Zhang Q, Kaur P, Yazdani HO, et al. MicroRNAs in colorectal cancer: role in metastasis and clinical perspectives.
Both H19 and miR-675 were up-regulated in human CRC cells primary human CRC tissues. The tumor suppressor retinoblastoma (RB) was a direct target of miR-675, and the H19-derived miR-675 could promote CRC cell proliferation by targeting the RB . Interestingly, the transcript of H19 also harbors canonical and non-canonical binding sites for some members of the let-7 family, which involves in the regulation of let-7 expression, and H19 can down-regulate let-7 expression by exerting its role of a molecular sponge [274, 275].
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